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Lipoxygenases and their involvement in programmed cell death (Review)

M Maccarrone, G Melino and A Finazzi-Agro


Cell Death and Differentiation (2001) 8, 776 - 784


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Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and the synthesis of signaling molecules. Consequently, they induce structural and metabolic changes in the cell in a number of pathophysiological conditions. Recently, a pro-apoptotic effect of lipoxygenase, and of the hydroperoxides produced thereof, has been reported in different cellsandtissues, leadingtocelldeath.Anti-apoptotic effects of lipoxygenases have also been reported; however, thishasoftenbeenbasedontheuseofenzymeinhibitors.Here we review the characteristics of the lipoxygenase family and its involvement in the initiation of oxidative stress-induced apoptosis. Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms.


1. KuÈhn H and Borngraber S (1999) Mammalian 15-lipoxygenases. Enzymatic properties and biological implications. Adv. Exp. Med. Biol. 447: 5 - 28

2. Grechkin A (1998) Recent developments in biochemistry of the plant lipoxygenase pathway. Prog. Lipid. Res. 37: 317 - 352

3. Brash AR (1999) Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 274: 23679 - 23682

4. Sudharshan E and Appu Rao AG (1999) Involvement of cysteine residues and domain interactions in the reversible unfolding of lipoxygenase-1. J. Biol. Chem. 274: 35351 - 35358

5. ClappCH,McKownJ,Xu H, GrandizioAM,YangGandFayer J (2000) The action of soybean lipoxygenase-1 on 12-iodo-cis-9-octadecenoic acid: the importance of C11-H bond breaking. Biochemistry 39: 2603 - 2611

6. Provost P, Samuelsson B and Radmark O (1999) Interaction of 5-lipoxygenase with cellular proteins. Proc. Natl. Acad. Sci. USA 96: 1881 - 1885

7. Datta K, Biswal SS and Kehrer JP (1999) The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem. J. 340: 371 - 375

8. Sandstrom PA, Pardi D, Tebbey PW, Dudek RW, Terrian DM, Folks TM and Buttke TM (1995) Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. FEBS Lett. 365: 66 - 70

9. He bertM-J, Takano T,HolthoÈ ferHand BradyHR(1996) Sequentialmorphologic events during apoptosis of human neutrophils. Modulation by lipoxygenasederived eicosanoids. J. Immunol. 157: 3105 - 3115

10. Aoshima H, Satoh T, Sakai N, YamadaM, Enokido Y, Ikeuchi T and Hatanaka H (1997) Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells. Biochim. Biophys. Acta 1345: 35 - 42

11. LiberlesSDand SchreiberSL (2000) Apoptosis-inducing natural products found in utero during murine pregnancy. Chem. Biol. 7: 365 - 372

12. O'Donnell VB, SpycherSand AzziA(1995) Involvement of oxidantsand oxidantgenerating enzyme(s) in tumour-necrosis-factor-a-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem. J. 310: 133 - 141

13. Maccarrone M, NieuwenhuizenWF, Dullens HFJ, Catani MV,MelinoG, Veldink GA, Vliegenthart JFG and Finazzi-AgroÁ A (1996) Membrane modifications in human erythroleukemia K562 cells during induction of programmedcell death by transforming growth factor b1 or cisplatin. Eur. J. Biochem. 241: 297 - 302

14. Wagenknecht B, Schulz JB, Gulbins E and Weller M (1998) Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing. Cell Death Differ. 5: 894 - 900

15. MaccarroneM, CataniMV,Finazzi-AgroÁ AandMelinoG(1997) Involvementof5- lipoxygenase in programmed cell death of cancer cells. Cell Death Differ. 4: 396 - 402

16. Croft KPC, Voisey CR and Slusarenko AJ (1990) Mechanism of hypersensitive cell collapse: correlation of increased lipoxygenase with membrane damage in leaves of Phaseolus vulgaris (L.) cv. RedMexican inoculated with avirulent race 1 of Pseudomonas syringae pv. phaseolicola. Physiol. Mol. Plant Pathol. 36: 49 - 62

17. Levine A, Tenhaken R, DixonRand LambC(1994)H2O2 from theoxidative burst orchestrates the plant hypersensitive disease resistance response. Cell 79: 583 - 593

18. Buonaurio R and Servili M (1999) Involvement of lipoxygenase, lipoxygenase pathway volatiles, and lipid peroxidation during the hypersensitive reaction of pepper leaves to Xanthomonas campestris pv. vesicatoria. Physiol. Mol. Plant Pathol. 54: 155 - 169

19. Rusterucci C, Montillet JL, Agnel JP, Battesti C, Alonso B, Knoll A, Bessoule JJ, Etienne P, Suty L, Blein JP and Triantaphylides C (1999) Involvement of lipoxygenase-dependent production of fatty acid hydroperoxides in the development of the hypersensitive cell death induced by cryptogein on tobacco leaves. J. Biol. Chem. 274: 36446 - 36455

20. MaccarroneM,VanZadelhoffG,Veldink GA,VliegenthartJFGand Finazzi-AgroÁ A(2000)Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmedcell death. Eur. J. Biochem. 267:5078 -5084

21. Zhou YP, Teng D, Dralyuk F, Ostrega D, RoeMW, Philipson L and Polonsky KS (1998) Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. J. Clin. Invest. 101: 1623 - 1632

22. Vernole P, Tedeschi B, Caporossi D, Maccarrone M, Melino G and Annicchiarico-Petruzzelli M (1998) Induction of apoptosis by bleomycin in resting and cycling human lymphocytes. Mutagenesis 13: 209 - 215

23. Maccarrone M, Fantini C, Ranalli M, Melino G and Finazzi-AgroÁ A (1998) Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells. FEBS Lett. 434: 421 - 424

24. Kamitani H, Geller M and Eling T (1998) Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation. J. Biol. Chem. 273: 21569 - 21577

25. Ikawa H, Kamitani H, Calvo BF, Foley JF and Eling TE (1999) Expression of 15- lipoxygenase-1 in human colorectal cancer. Cancer Res. 59: 360 - 366

26. Kamitani H, Ikawa H, Hsi LC, Watanabe T, DuBois RN and Eling TE (1999) Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. Arch. Biochem. Biophys. 368: 45 - 55

27. Matyshevskaia OP, Pastukh VN and Solodushko VA (1999) Inhibition of lipoxygenase activity reduces radiation-induced DNA fragmentation in lymphocytes. Radiat. Biol. Radioecol. 39: 282 - 286

28. Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE, Lotan R, Fischer SM and Lippman SM (2000) 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. J. Natl. Cancer Inst. 92: 1136 - 1142

29. SuretteME,FontehAN,BernatchezCandChiltonFH(1999) Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells. Carcinogenesis 20: 757 - 763

30. Tang DG, Guan K-L, Li L, Honn KV, Chen YQ, Rice RL, Taylor JD and Porter AT (1997) Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids. Int. J. Cancer 72: 1078 - 1087

31. Szekeres CK, Tang K, Trikha M and Honn KV (2000) Eicosanoid activation of extracellular signal-regulated kinase 1/2 in human epidermoid carcinoma cells. J. Biol. Chem. 275: 38831 - 38841

32. Biswal SS, Datta K, Shaw SD, Feng X, Robertson JD and Kehrer JP (2000) Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicol. Sci. 53: 77 - 83

33. Maccarrone M, Ranalli M, Bellincampi L, Salucci ML, Sabatini S, Melino G and Finazzi-AgroÁ A (2000) Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. Biochem. Biophys. Res. Commun. 272: 345 - 350

34. MetzlerB,HuY,SturmG, WickGandXuQ(1998) Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells. J. Biol. Chem. 273: 33320 - 33326

35. Buyn T, Dudeja P, Harris JE, Ou D, Seed T, Sawlani D, Meng J, Bonomi P and Anderson KM (1997) A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death. Prostaglandins Leukot. Essent. Fatty Acids 56: 67 - 77

36. Aoshiba K, Yasui S, Nishimura K and Nagai A (1999) Thiol depletion induces apoptosis in cultured lung fibroblasts. Am. J. Respir. Cell. Mol. Biol. 21: 54 - 64

37. Ghosh J andMyersCE(1998) Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis inhuman prostate cancer cells.Proc. Natl.Acad. Sci.USA95: 13182 - 13187

38. Tang K, Nie D and Honn KV (1999) Role of autocrine motility factor in a 12- lipoxygenase dependent anti-apoptotic pathway. Adv. Exp. Med. Biol. 469:583 - 590

39. VanagsDM,LarssonP,FeltenmarkS, JakobssonP-J,OrreniusS,ClaessonH-E and Aguilar-Santelises M (1997) Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells. Cell Death Differ. 4: 479 - 486

40. Jang M, Cai L, UdeaniGO, Slowing KV, Thomas CF, BeecherCWW,Fong HHS, Farnsworth NR, Kinghorn AD, Metha RG, Moon RC and Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218 - 220

41. Maccarrone M, Lorenzon T, Guerrieri P and Finazzi-AgroÁ A (1999) Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur. J. Biochem. 265: 27-34

42. Gehm BD, McAndrews JM, Chien PY and Jameson JL (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA 94: 14138 - 14143

43. Sud'inaGF, MirzoevaOK, PushkarevaMA,KorshunovaGA,SumbatyanNVand Varfolomeev SD (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329: 21 - 24

44. Maccarrone M, Taccone-Gallucci M, Meloni C, Cococcetta N, Manca di Villahermosa S, Casciani U and Finazzi-AgroÁ A (1999) Activation of 5-lipoxygenase and related cell membrane lipoperoxidation in hemodialysis patients. J. Am. Soc. Nephrol. 10: 1991 - 1996

45. Schnurr K, Belkner J, Ursini F, Schewe T and Kuhn H(1996) The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products. J. Biol. Chem. 271: 4653 - 4658

46. Fadok VA, XueDandHenson P (2001) If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer. Cell Death Differ. 8: 582 - 587

47. Van Leyen K, Duvoisin RM, EngelhardtHand WiedmannM(1998) A function for lipoxygenase in programmed organelle degradation. Nature 395: 392 - 395

48. Vieira HLA, Haouzi D, El Hamel EI, Jacotot E, Belzacq A-S, Brenner C and KroemerG(2000) Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. Cell Death Differ. 7: 1146 - 1154

49. Bernardi P, Petronilli V, Di Lisa F and ForteM(2001)Amitochondrial perspective on cell death. Trends Biochem. Sci. 26: 112 - 117

50. Maccarrone M, Lorenzon T, Bari M, Melino G and Finazzi-AgroÁ A (2000) Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J. Biol. Chem. 275: 31938 - 31945

51. Von Ahsen O, Waterhouse NJ, Kuwana T, Newmeyer DD and Green DR (2000) The `harmless' release of cytochrome c. Cell Death Differ. 7: 1192 - 1199

52. Roucou X and Martinou J-C (2001) Conformational change of Bax: a question of life or death. Cell Death Differ. 8: in press

53. Maccarrone M, Salucci ML, Melino G, Rosato N and Finazzi-AgroÁ A (1999) The earlyphase ofapoptosis inhumanneuroblastomaCHP100cells is characterized by lipoxygenase-dependent ultraweak light emission. Biochem. Biophys. Res. Commun. 265: 758 - 762

54. Morel J-B andDangl JL (1997) The hypersensitive response and the induction of cell death in plants. Cell Death Differ. 4: 671 - 683

55. HilbersMP, Finazzi-AgroÁ A,VeldinkGAandVliegenthartJFG(1996)Purification and characterization of a lentil seedling lipoxygenase expressed in E. coli. Int. J. Biochem. Cell Biol. 28: 751 - 760

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