The growth of the cell death field: an analysis from the ISI-Science citation index

Eugene Garfield and Gerry Melino


Cell Death and Differentiation (1997) 4, 352 - 361


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It is salutary to reflect that programmed cell ceath (PCD) was first defined as a morphogenetic process over 30 years ago, and apoptosis was defined as a non-inflammatory mechanism for the removal of single cells from complex organs nearly 25 years ago. For many years, these remained essentially descriptive phenomena, and it was not until the recognition of similar processes in C. elegans, the identification of those genes regulating nematode apoptosis and the realization that these nematode genes have mammalian homologues, that the field began to expand exponentially. We have asked Andrew Wyllie, John Kerr and Richard Lockshin, some of the pioneers of apoptosis to review the scientific progress of apoptosis. The comments of Richard Lockshin (1997) accompany this paper.


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